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One aim of every therapy of periodontitis or periimplantitis is the elimination or at least disintegration of the biofilm on the root or implant surfaces, resulting in an improvement of the periodontal or periimplant inflammation, probing depths and clinical attachment levels. Non-surgical removal of subgingival biofilm and concrements can be achieved by manual and or mechanical instrumentation of root or implant surfaces. Antiseptics, antibiotics, photodynamic therapy, laser and probiotics can be used adjuvantly and improve clinical results in certain cases. This lecture shows research-based evidences and discusses the clinical implications for non-surgical periodontitis or periimplantitis therapy.