Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder. The oral manifestations of the syndrome include rapidly progressive periodontal disease resulting in premature exfoliation of primary and permanent dentitions. Patients are often edentulous at an early age and require prosthodontic treatment. This report is the oral rehabilitation of an edentulous 25-year-old female with PLS. Treatment included grafting the maxillary arch using iliac crest bone and both the maxilla and mandible were restored using screw type ﬁxed prostheses supported by 13 osseointegrated dental implants. At the 1-year and 2- years follow-up, the patient presented signiﬁcant improvements in oral function and psychosocial activities and no prosthetic complications.