Introduction. Repeated fracture of acrylic denture occurs at the repair joints or within the repair materials due to its weak strength. Several studies were done to improve the repair bond strength along with repair materials reinforcement. However, repair surface treatment combined with bonding agents application aren’t investigated. Therefore, this study aimed to evaluate the combination effect of mechanical surface treatment with intermediate bonding agents and ZrO2 nanoparticles (nano-ZrO2) addition to repair material on the shear bond strength (SBS) of repaired denture base. Methodology: Heat-polymerized acrylic resin was used to fabricate 130 cylindrical blocks 15 mm diameter and divided into control group without treatment (C, n=10), while the repair bonding area of remaining specimens were treated with alumina-blasting and divided into 3groups (n=40); specimens treated with alumina-blasting alone (AB), combined with silane coupling agent (AB+SCA), or with methyl methacrylate based composite bonding agent (AB+MA). Treated groups were subdivided according to nano-ZrO2 concentrations into 0%, 2.5%, 5%, and 7.5% of repair resin powder. Repair resin was applied to the bonding area and polymerized at 37°C for 10 minutes. SBS (MPa) was performed using universal testing machine. Tukey-Kramer multiple-comparison test was performed to identify the significant differences between groups (P≤0.05). Results. SBS of alumina-blasted denture base specimens with application of intermediate agents were significantly increased in comparison with control group (P<0.05), while no significant difference between AB and control group (P>0.05). Nano-ZrO2 addition significantly increased SBS except for AB, and 5%, 7.5% MA (P>0.05). Conclusion. Bonding agents applications to the alumina-blasted repair surface improved the repair bonding strength and could be used as a new adhesive method for denture repair. Moreover, nano-ZrO2 addition with surface treatment improved the repair bond strength.